Words 'Coverage without hassles, You got it'
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Icon of Trudhesa™ nasal spray symbolTrudhesa Direct™ for at-home delivery and savings. No hoops. No hassles. No kidding.
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Get Trudhesa® for as little as $0 per prescription*

If you have commercial medical insurance, your first prescription copay will be $0, guaranteed, once you're enrolled in the Trudhesa Direct Savings Program*

Copay savings without the copay card

Your copay savings will be applied starting with your very first prescription, without the need to carry around a copay card.


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Getting Trudhesa
in just 3 steps
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Your healthcare provider (HCP) sends a prescription of Trudhesa to one of our digital pharmacy partners:
Phil: Icon of phone1-855-588-0387, option 1
Carepoint: Icon of phone1-855-237-9112, option 2
ASPN: Icon of phone1-866-892-0038

Note: Trudhesa is available exclusively through Trudhesa Direct.

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You will receive text messages to:
  • Confirm your prescription has been received
  • Enroll in the patient savings program. You pay as little as $0 per prescription (if you're commercially insured)*
  • Schedule your home delivery of Trudhesa at no additional cost

Be sure you respond to these important texts!

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Trudhesa arrives at your doorstep

And repeat: When it’s time to refill your prescription, you’ll simply get another text from the pharmacy.

If you don't receive a text from Trudhesa Direct, call 1-833-TRUDHESA (833-878-3437).

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Impel Pharmaceuticals Patient Assistance Program is here to help

If you’re facing financial hardship or have limited or no insurance coverage, you can enroll in the Impel Pharmaceuticals Patient Assistance Program by calling customer care at 1-833-TRUDHESA (833-878-3437) option 2.

*Terms and Conditions: The pharmacy will enroll you into the Trudhesa Direct™ Patient Savings Program. This offer cannot be redeemed for cash. Each time the offer is used, you are certifying that you meet the eligibility criteria and will comply with the terms and conditions described in the Restrictions section below. If you have any questions about this offer, please call 1-833-TRUDHESA (833-878-3437).
Restrictions: This offer is valid in the United States only. Offer is available if a patient has a prescription, is commercially insured and is 18 years or older. Offer is not valid for patients who use any state or federal government-funded healthcare program to cover a portion of medication costs, such as Medicare (including Medicare Part D), Medicaid, Medigap, TRICARE, Department of Defense (DOD), Veterans Administration (VA), patients who are cash-paying or where prohibited by law. By using this offer, the patient certifies that he or she will comply with any terms of his or her insurance plan. It is illegal to (or offer to) sell, purchase, or trade this offer. Void where prohibited by law. This program does not constitute health insurance. Program managed by ConnectiveRx on behalf of Impel Pharmaceuticals. The parties reserve the right to rescind, revoke or amend this offer without notice at any time.
Standard messaging rates apply.
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Serious or potentially life-threatening reductions in blood flow to the brain or extremities due to interactions between dihydroergotamine (the active ingredient in Trudhesa) and strong CYP3A4 inhibitors (such as protease inhibitors and macrolide antibiotics) have been reported rarely. As a result, these medications should not be taken together.
Trudhesa is used to treat an active migraine headache with or without aura in adults. Do not use Trudhesa to prevent migraine when you have no symptoms. It is not known if Trudhesa is safe and effective in children.
Do not use Trudhesa if you:
  • Have any disease affecting your heart, arteries, or blood circulation
  • Are taking certain anti-HIV medications known as protease inhibitors (such as ritonavir or nelfinavir)
  • Are taking a macrolide antibiotic such as clarithromycin or erythromycin
  • Are taking certain antifungals such as ketoconazole or itraconazole
  • Have taken certain medications such as triptans or ergot-type medications for the treatment or prevention of migraine within the last 24 hours
  • Have taken any medications that constrict your blood vessels or raise your blood pressure
  • Have severe liver or kidney disease
  • Are allergic to ergotamine or dihydroergotamine
Before taking Trudhesa, tell your doctor if:
  • You have high blood pressure, chest pain, shortness of breath, heart disease; or risk factors for heart disease (such as high blood pressure, high cholesterol, obesity, diabetes, smoking, strong family history of heart disease or you are postmenopausal, or male over 40); or problems with blood circulation in your arms, legs, fingers, or toes.
  • You have or had any disease of the liver or kidney.
  • You are taking any prescription or over-the-counter medications, including vitamins or herbal supplements.
  • You are pregnant, planning to become pregnant or are nursing, or have ever stopped medication due to an allergy or bad reaction.
  • This headache is different from your usual migraine attacks.

The use of Trudhesa should not exceed dosing guidelines and should not be used on a daily basis.

Serious cardiac (heart) events, including some that have been fatal, have occurred following the use of dihydroergotamine mesylate, particularly with dihydroergotamine for injection, but are extremely rare.

You may experience some nasal congestion or irritation, altered sense of taste, sore throat, nausea, vomiting, dizziness, and fatigue after using Trudhesa.

Contact your doctor immediately if you experience:

  • Numbness or tingling in your fingers and toes
  • Severe tightness, pain, pressure, heaviness, or discomfort in your chest
  • Muscle pain or cramps in your arms or legs
  • Cold feeling or color changes in 1 or both legs or feet
  • Sudden weakness
  • Slurred speech
  • Swelling or itching

The risk information provided here is not comprehensive. To learn more, talk about Trudhesa with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at www.trudhesa.com or 1-800-555-DRUG. You can also call 1-833-TRUDHESA (1-833-878-3437) for additional information.